Job: Research Scientist, Metabolism/DDI

Jobing Description

Reports To:

Senior Director, Preclinical Candidate Selection

Basic Function:

Work as a member of the Preclinical Candidate Section (PCS) team supporting the progression of candidate compounds from lead selection through development. This is a hands-on, bench scientist, role studying in vitro metabolism and transporter interactions of compounds in development.

Essential Duties:

* Provide technical support or expertise related to in vitro ADME assays including: in vitro metabolism, cytochrome P-450 inhibition and reaction phenotyping assays, and others; conduct assays as needed.
* Conduct cytochrome P-450 reaction phenotyping experiments including correlation analysis, recombinant enzymes and specific cytochrome P-450 inhibitors
* Work closely with bioanalytical group members to characterize metabolic pathways and structural elucidation, when necessary, to support product labeling and also identify potential drug-drug interactions
* Provide support for identification and implementing new strategies to enhance DMPK assays in discovery and development.
* Design and manage the conduct of outsourced pharmacokinetic and ADME studies by CROs, when needed.

Other Duties:

* Participate on discovery and early development project teams
* Expand the capabilities of the PCS group through the development and execution of new assays and ADMET techniques
* Preparation of written final reports
* Other duties as assigned

Job Requirements

Core Competencies:

Excellent analytical/problem solving skills with the ability to critically evaluate experimental data and integrate the results into the drug discovery and development process. Strong attention to detail is required. Outstanding organizational skills plus the ability to properly prioritize and multitask. Ability to work independently as well as function effectively within a team environment.

Knowledge of:

Knowledge of, and hands on experience with, the role of DMPK in drug development and regulatory perspectives on drug-drug interactions is required. Knowledge to integrate in vivo pharmacokinetic results with underlying transport or metabolic processes. Knowledge of drug metabolizing enzymology and kinetics. Microsoft Office products and Prism software.

Education:

Ph.D. in Biochemistry, Pharmacology, Toxicology, or related scientific field

Experience:

3-5 years pharmaceutical industry experience with in vitro drug metabolism. Demonstrated experience using concepts related to Cytochrome P450 enzymology and kinetics to conduct robust cytochrome P-450 reaction phenotyping experiments for compounds in development. Experience in the drug development process and project team interaction. Experience with one, or more, of the following areas: Cytochrome P-450 enzyme kinetics and in vitro assays, Biotransformation, Pharmacokinetics, Transporter regulation and function.